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Allergologie et Immunopathologia (Madrid). 2010 May-June; 38 (3): 142-6. In this study, styling itself as a “gold standard, double-blind placebo controlled, crossed-over challenge,” 26 adults with atopy (skin or asthma allergy) were tested for tartrazine (Yellow 5) sensitivity and had … Continue reading
PROLOGUE “What is the loss of job, career, professional license, honors, colleagues, and country against that of a child’s voice? How do the very public denigration of one’s science and the epithet of “child killer” from Bill Gates weigh against … Continue reading
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Archives of Disease in Childhood. 2003 July; 88(7): 595-600. Newson here proposes that PDA should be considered a separate entity within the pervasive developmental disorders. Table 1 on Page 597 gives a detailed description of such a child, using 8 … Continue reading
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Autism. 2014, July; 18(5): 538-44. This is the first report comparing the profiles of children labelled PDA to those in other groups with behavioral overlap. For example, children with conduct problems are strongly motivated by rewards; for PDA, however, rewards … Continue reading
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Research in Developmental Disabilities. 2014 Dec; 35(12): 3236-44 Children with epilepsy often have other neurological problems such as autism and ADHD. This paper is a detailed report on four children with epilepsy as well as symptoms of PDA (Pathological Demand … Continue reading
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Journal of Child Psychology and Psychiatry. 2014 July; 55(7):769-70 Beginning with a comment on “PDA” as sometimes used to mean “Public Display of Affection,” Gillberg says that in his own 40 years of clinical experience, PDA/EDA is not at all … Continue reading
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European Child & Adolescent Psychiatry. 2015. August; 24(8): 979-84. The Faroe Islands are a cluster of 18 rocky, volcanic islands which form a self-governing archipelago, part of the Kingdom of Denmark. They are located in the open seas between the … Continue reading
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Journal of Child Psychology and Psychiatry 55:7 (2014), pp 758–768 This paper is about the development and validation of the ‘Extreme Demand Avoidance Questionnaire’ (EDA-Q), to aid in diagnosis of PDA (Pathological Demand Avoidance) traits. PDA (or EDA) is a … Continue reading
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European Child & Adolescent Psychiatry. 2016 April; 25(4): 407-19 The term “pathological demand avoidance” (PDA) describes children or adults within the autism spectrum who exhibit obsessive resistance to everyday demands and requests. In this study, the authors determined specific differences … Continue reading
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Acta Histochemica. 2017 March; 119(2): 172-180 The authors used a rat model to answer the following questions: Does exposure to tartrazine (Yellow 5) influence the rats’ memory and learning? Does the tartrazine exposure have any effects on the volume of … Continue reading
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American Journal of Epidemiology, 2016 Aug 1; 184(3):227-32 Giving pregnant women the flu shot is expected not only to prevent the flu in both mothers and newborns, but also to prevent adverse pregnancy outcomes such as preterm birth. According to … Continue reading
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European Child & Adolescent Psychiatry. Sep;26(9): 1067-1079 In her review of the research, Dr. Ly discusses the use of elimination diets for ADHD and autism from the point of view of the interaction of the metabolic, immune, endocrine, and neural … Continue reading
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Pediatrics, 2017 Jan 30. pii: e20162027 This study took place in Spain, where families have a long tradition of eating the Mediterranean diet. As diets today veer away from traditional healthful foods towards junk food, candies and convenience foods, behavior … Continue reading
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This Gary Null Production is a long film – almost 2 hours – so get comfortable before you start. Although some parents are quoted in this film, most of the participants are medical doctors and researchers. ADDED Oct. 1, 2023: … Continue reading
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Environmental Health, Feb 27;14:17. doi: 10.1186/s12940-015-0003-1. The authors comment that while environmental factors known to increase the risk of ADHD include exposure to manganese, poly-chlorinated biphenyls (PCBs), nicotine, mercury, arsenic, food additives, food coloring, pesticides and lead, almost no attention … Continue reading
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Fluoride, 39 (4), 293-301. Giving adult male rats 100 ppm and 300 ppm (parts per million) of sodium fluoride in their drinking water for 12 weeks resulted in less testosterone, fewer (and weaker) sperm, less aggressive behavior, and less successful … Continue reading
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PLoS One. 2014 Oct 22;9(10): e110509. If you must handle thermal receipts, don’t use sanitizers or hand lotion – both often contain chemicals that will encourage the BPA to slide right through your skin. In the experiment described in this … Continue reading
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Child Care Health & Development. 2015 May;41 (3):424-33 This study examines the “mechanisms by which food advertising prompts children’s consumer behavior.” The children respond to advertising by (1) an increase in expectations and purchase motivation, (2) happiness upon acquiring the … Continue reading
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The Journal of Clinical Psychiatry. 2016 Oct;77(10): e1342-e1347 Drugs used for bipolar disorder often work by down-regulating the brain metabolism of a long-chain omega-6 (or n-6) essential fatty acid called arichidonic acid (AA). The shorter-chain omega-6 (or n-6) essential fatty … Continue reading
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Otolaryngology Head & Neck Surgery. 2015 Jan; 152(1): 42-47. Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetyl-salicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment may include steroids, surgery, and/or aspirin desensitization. In this study of 10 patients, … Continue reading
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International Forum of Allergy & Rhinology. 2016. April; 6(4): 385-91 30 patients diagnosed with aspirin sensitivity and aspirin-exacerbated respiratory disease (AERD) were entered into a diet trial. They ate either a regular diet or a low-salicylate diet for 6 … Continue reading
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Acta Otorhinolaryngologica Belgica. 1995;49(3): 235-50. In this review of aspirin-sensitive rhinosinusitis, it is described as a non-allergic, non-infectious perennial eosinophilic rhinitis starting in middle age and rarely seen in children. It may also been seen in atopic patients who have … Continue reading
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Childs Nervous System. 2011 May;27(5): 793-802 This is one of the first studies to investigate the relationship between dietary components and Tourette syndrome (TS). Using the laboratory that tested the Olympic Games contestants for illegal stimulant drugs, the researchers tested … Continue reading
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Mutation Research. 2002 Aug 26; 519(1-2): 103-19. Sasaki et al, in Japan, tested 39 common food additives — dyes, color fixatives, preservatives, antioxidants, fungicides, and sweeteners. They gave each additive separately by mouth to groups of four male mice, and … Continue reading
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Annals of General Psychiatry (2015) March 1; 14:12 This was a study on children with ADHD in Iran who were already receiving Ritalin therapy, to see if improving their diet in general might make a difference. The children were divided … Continue reading
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Journal of Food Science. 2013 April; 78(4): T642-7 This is the first national study on food additive use in India, collecting data on “sweets and savories.” Their dye extraction and identification technique (using pure wool strands) is described, as is … Continue reading
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Journal of Attention Disorders, Vol. 3(1): 30-48 (1999) This review of “alternative” treatments was undertaken for the National Institute of Health (NIH) 1998 Consensus Development Conference on ADHD. 23 treatments were identified. Some were considered effective or possibly effective for … Continue reading
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Journal of the American Academy of Child and Adolescent Psychiatry. 2012 Jan; 51(1): 86–97.e8. This meta-analysis of 24 published studies on food colors, plus 10 more on dietary restriction, concluded that a restriction diet (e.g., the Feingold diet or an … Continue reading
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Pediatric Nursing. 2007 Mar-Apr; 33(2): 138-43. This review is intended to help nurses support parents who want to try various therapeutic diets such as the Feingold diet, oligoantigenic (few foods) diet, or gluten-free, casein-free diet for their children. The nurses … Continue reading
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Journal of Paediatrics and Child Health. 1997 June; 33(3): 190-4. The author summarizes and discusses the research from the 1970s up until the 1990s. She emphasizes that studies often only can deal with a single item but in actuality there … Continue reading
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Applied Psychophysiology and Biofeedback, 2003 March; 28(1): 63-75. In this paper, Schnoll reviews the research on food additives, refined sugars, food allergies, and fatty acid metabolism as it relates to ADHD. QUOTE: “Although clinicians and researchers alike acknowledge the complex … Continue reading
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Roczniki Panstwowego Zakladu Higieny. 2012;63(2): 127-34 In this review of ADHD treatments, Konikowska describes hyperactivity as a genetic trait connected to abnormal brain maturation, likely related to less activity by neurotransmitters dopamine and norepinephrine. While stimulant medications effectively increase the … Continue reading
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Scientific Reports, 2016 Jan 5;6:18989. Air pollution is good for something …. if you are a pigeon racer. It seems that in northern China, homing pigeons fly home lots faster through polluted air. The authors say it isn’t yet clear … Continue reading
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The Journal of Toxicological Sciences, Vol. 37, No. 6, 1247-1252. 2012 By studying the brains of mice whose mothers were exposed to titanium dioxide (TiO2) nanoparticles during pregnancy, the researchers determined changes in gene expression affecting several parts of the … Continue reading
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Scientific Reports, 2016 March 31;6:23819 The purpose of this study was to better understand how the widely used titanium dioxide may impact the environment. The researchers used swallowtail butterfly larvae which were hatched on plants growing in water containing titanium … Continue reading
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Acupuncture & Electro-Therapeutics Research., Vol. 40, pp. 157-187, 2015 Omura reports on a non-invasive method developed to detect neurotransmitters, bacteria, metals, virus, and other abnormal molecules using an electromagnetic field resonance phenomenon through the pupil of the eye. The researchers … Continue reading
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Environmental Monitoring and Assessment. (2016) 188:575 This Swiss study looks at the effect of two kinds of nanoparticles, separately and combined. Both copper oxide (CuO) and titanium dioxide (TiO2) ultrafine particles (nanoparticles or NP) are widely used in many things … Continue reading
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Nanotoxicology. 2016 Sep;10(7):902-12. In this study, 25 µg/L and 250 µg/L of the food color additive titanium dioxide (TiO2) nanoparticles were added to outdoor mesocosms* placed in a lake. The control mesocosm was not treated with any TiO2. * A … Continue reading
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Journal of Biomedical Materials Research Part A. 2014 Feb; 102(2): 470-8. Titanium dioxide is a naturally occurring white powder approved by the FDA. It is used as a white coloring in many products we use every day such as toothpaste, … Continue reading
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The New Microbiologica, 2016. July ;39(3): 228-231. Endogenous Retroviruses in humans (HERVs) are derived from ancient viral infections which over time became part of the usual human genome. In fact, they make up 8% of the total genome (98,000 fragments, … Continue reading
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The Australian and New Zealand Journal of Psychiatry. 2016 Sep 30. doi: 10.1177/0004867416670013 The researchers analyzed the records of 1,233 infants, whose parents filled out an ADHD questionnaire when the child was a little less than 3 years old. They … Continue reading
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Toxicology and Industrial Health, 2013. March; 29(2): 224-32. doi: 10.1177/0748233711433935 The researchers wanted to evaluate the toxic effect of some synthetic colorants and/or flavors on body organs and metabolism in rats. They used 10 groups of 10 male albino rats … Continue reading
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Journal of Allergy and Clinical Immunology, 2000 Mar;105(3):462-7 In this study, a questionnaire was filled out by 366 adult asthma patients. Over 33% of them said that their asthma had been triggered by alcohol at least twice, with wine reported … Continue reading
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Schweizerische medizinische Wochenschrift (Swiss medical weekly), 1981. Sep 26; 111(39): 1445-50 Wuthrich wrote that adverse reactions to aspirin, additives such as tartrazine (Yellow 5) and the preservative benzoate are seen all over the world. It is described as an intolerance … Continue reading
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Journal of Allergy & Clinical Immunology, 1979 Dec;64(6 Pt 1):500-6 In this study, a positive response was defined as a 20% fall in forced expiratory volume in 1 second (FEV1) for up to 4 hours. The researchers tested several hundred … Continue reading
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Tohoku Journal of Experimental Medicine, 1979. Nov; 129(3): 303-9. In this study on guinea pigs, the researchers showed that the dye Yellow 5 potentiates asthmatic reactions to other broncho-constrictors. In other words, the dye may not cause an asthma attack … Continue reading
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Prenatal Diagnosis. 2016, Sep 29. doi: 10.1002/pd.4932 Edlow reviews the current animal and human research showing a connection between maternal (and sometimes paternal) obesity and high fat diets on neuro-developmental and psychiatric disorders in the offspring. These disorders include cognitive … Continue reading
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Life Sciences. 1980 Nov 17;27(20):1897-904. In this study, some rats were treated with 6-OHDA and some were treated with placebo. In each of these groups, some were given food dyes and some were given placebo, resulting in 4 groups of … Continue reading
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Toxicology International. 2015 Jan-Apr; 22(1): 152–157. This study was done to see if the common food colors tartrazine (Yellow 5), metanil yellow (a non-permitted color often used illegally) and sunset yellow (Yellow 6) may play a part in liver disease. … Continue reading
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Journal of Attention Disorders. 2010 Jun 23. In Norway, the Prescription Database contains information on all prescription drugs dispensed since 2001, which creates a unique opportunity to address the issue of whether the diagnoses of ADHD and asthma are associated … Continue reading
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Journal of Clinical Epidemiology, 1995. Oct;48(10):1269-75 Corder estimated safe doses to use for epidemiological studies by studying reactions of patients in an allergy clinic. He said that reactions to the four compounds listed in the table are common, and may … Continue reading
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British Journal of Dermatology, 2008. Dec;159(6):1368-9. This is a case report of several patients with disabling salicylate-induced intolerance including severe urticaria, asthma, and anaphylactic reactions. After dietary supplementation with 10 g daily of fish oils rich in omega-3 for 6-8 … Continue reading
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The Journal of Allergy & Clinical Immunology, 113(2), Suppl, S32 Both Levalbuterol (LEV) and racemic Albuterol (RAC) are bronchodilator medications used for asthma, but parents complain that children are more restless and hyperactive after taking LEV. In this study, attention … Continue reading
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International Journal of Environmental Research and Public Health, 2016 July 4;13(7). pii: E678. In this study of Taiwanese children, a strong correlation was found between amount of sugar-sweetened beverages (SSB) consumed per day and ADHD. A dose-response effect was observed, … Continue reading
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Annual Review of Public Health, 2015 Mar 18;36:211-30. The objective of this review is to provide an overview on the population impact of toxins on the developing brain and describe implications for public health. QUOTE: “The blood–brain barrier of the … Continue reading
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Physiology & Behavior, 135 (2014), 174-179. SULT1A inhibitors in foods, including natural substances and artificial food colors, have a role in ADHD that can both worsen or improve symptoms. … SULT1A inhibition can influence brain catecholamines through the intermediary of … Continue reading
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Clinical Allergy. 1978 Jan;8(1): 65-8. In an Israeli hospital, Neuman et al tested the effect of 50 mg of tartrazine (Yellow 5) on 97 patients with a variety of allergic disorders and 25 with non-allergic rhinitis. First, all patients were … Continue reading
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Cell Metabolism, 2016 July 12;24(1): 75-90 Both flies and mice have the same pathways which are triggered by sucralose (Splenda) to make the body think it is starving and increase the desire to eat. Wang explains that a sweet taste … Continue reading
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Little Debbie Swiss Rolls Use Yellow, Red, and Blue Dyes to Make ‘Chocolate’ Cake Reprinted from article published by the Center for Science in the Public Interest, July 18, 2016 Little Debbie Swiss Rolls have a combined 32 milligrams of … Continue reading
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Environmental Health Perspectives, 2012. Jul;120(7): 935-43. In this study, the authors measured chemicals in cosmetics, personal care products, cleaners, sunscreens, and vinyl products, to determine what they contain in the way of asthma-causing chemicals and endocrine disruptors (chemicals that mess up … Continue reading
