Category Archives: Research Studies

Heidary 2020: Ivermectin–A systematic review from antiviral effects to COVID-19 complementary regimen

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The Journal of Antibiotics, 73: 593-602. This is a comprehensive systematic review, summarizing the antiviral effects of ivermectin over the past 50 years. Ivermectin plays a role in several biological mechanisms; therefore it could serve as a potential candidate in … Continue reading

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Abd-Elsalam 2021: Clinical study evaluating the efficacy of ivermectin in COVID-19 treatment: A randomized controlled study

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Journal of Medical Virology, Oct;93(10):5833-5838 In an effort to see if Ivermectin would be effective in patients hospitalized with Covid-19, the authors gave half of them 12 mg of the drug for 3 (three) days.   There were 82 patients in … Continue reading

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Aaby 2018: Evidence of increase in mortality after the introduction of Diphtheria-Tetanus-Pertussis vaccine to children aged 6-35 months in Guinea-Bissau: A time for reflection?

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Frontiers in Public Health, Mar 19;6:79 Dr. Aaby was involved in the original introduction of the DPT vaccine to children in this African country in 1981.   Even now, it is the most commonly used vaccine in low-income countries with poor … Continue reading

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Schumann 2020: Immune-modulating drug MP1032 (Remdesivir) with SARS-CoV-2 antiviral activity in vitro: A potential multi-target approach for prevention and early intervention treatment of COVID-19

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International Journal of Molecular Sciences. 21(22):8803. This is a complex study of Remdesivir’s activity against the cytokine storm sometimes seen in cases of Covid-19. MP1032 (Remdesivir) is a reactive-oxygen scavenger (ROS) and was originally being developed to treat psoriasis, rheumatoid … Continue reading

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Kory 2021: Review of the emerging evidence demonstrating the efficacy of Ivermectin in the prophylaxis and treatment of COVID-19

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American Journal of Therapeutics 28, e2999-e318 This is a meta-analysis of 18 randomized controlled treatment trials of ivermectin for COVID-19. CONCLUSIONS:  The meta-analysis found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, … Continue reading

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Harvard Studies on VAERS

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Lately, I  have been asked to “prove” that the VAERS system for tracking vaccine injuries reports only a small percentage (less than 1%) of those injuries.  I have also been asked to discuss whether such injuries are verified, and how.  … Continue reading

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Brownstein 2020: A novel approach to treating COVID-19 using nutritional and oxidative therapies

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Science, Public Health Policy, and the Law, Volume 2: 4-22. July 2020 Of 107 patients diagnosed with COVID-19 were given individualized treatments of Vitamin A,  Vitamin C, Vitamin D, Iodine, Nebulized and/or IV Hydrogen Peroxide, intramuscular therapies, IV Vitamin C, … Continue reading

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California’s done it!!!

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In 2017, California began to review the science on food dyes and behavior.   The CSPI requested me to send a collection of studies to them, which you can see here. Today they released their Final Report. The Report concludes that: … Continue reading

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Wopara 2021: Anxiogenic and memory impairment effect of food color exposure: Upregulation of oxido-neuroinflammatory markers and acetyl-cholinesterase activity in the prefrontal cortex and hippocampus

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Heliyon 7 (2021) e06378 Various doses of Erythrosine (Red 3) and Tartrazine (Yellow 5) were given to rats for six weeks. At that time, their behavior and ability to recognize objects was evaluated. At the end, their brains were studied … Continue reading

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Wopara 2020: Synthetic food dyes cause testicular damage via up-regulation of pro-inflammatory cytokines and down-regulation of FSH-R and TESTK-1 gene expression

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JBRA Assisted Reproduction.  Online ahead of print Every now and again the rumor surfaces that soda can cause infertility or a lower sperm count.  According to Live Science, this is an urban myth. In fact, they say Mountain Dew (a … Continue reading

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Derwand 2020: COVID-19 outpatients: Early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: A retrospective case series study

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International Journal of Antimicrobial Agents. Dec;56(6):106214. Most studies of Covid-19 involve very sick hospitalized patients. The authors are testing the use of Hydroxycholoroquine (HCQ) plus zinc and an antibiotic (for prevention of secondary lung infection) as an early treatment beginning … Continue reading

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Abd-Elsalam 2020: Hydroxychloroquine in the treatment of COVID-19: A multicenter randomized controlled study

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American Journal of Tropical Medicine & Hygiene. 103(4), pp. 1635-1639 From the chart, you might think that the authors would  have concluded that HCQ (Hydroxychloroquine) is a useful treatment for Covid-19, but according to their statistical analysis, they actually concluded … Continue reading

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What About Colostrum?

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All mammals nurse their young, feeding them milk produced in their mammary glands. Before the “true” milk itself is produced, however, another fluid called colostrum is provided. It is rich in nutrients as well as various growth factors; it is … Continue reading

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Lykkesfeldt 2019: The Pharmacokinetics of Vitamin C

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Nutrients. 11, 2412. Review. Although humans have the gene to make Vitamin C (as most other animals do), that gene is inactive.  Thus, humans must get it solely from dietary sources.   Because of the way it is taken up and … Continue reading

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Bosch 2020: A two arm randomized controlled trial comparing the short and long term effects of an elimination diet and a healthy diet in children with ADHD (TRACE study). Rationale, study design and methods.

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Study Protocol. BioMed Central Ltd. Psychiatry. 20: 262 This study has not yet happened.  It is intended to compare two dietary treatments (an elimination diet and a “healthy” diet) and  “Care As Usual” (medication).  It is being done in the … Continue reading

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Llewellyn 2020: Food color additives in the US food supply: Review of neurobehavioral safety

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Journal of Pediatric Neurology & Neuroscience. 4(1), 55-72. Case Report. This study was funded by the International Association of Color Manufacturers (IACM)  in response to the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA), which became concerned … Continue reading

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Al-Zalabani 2019: Association between soft drinks consumption and asthma: A systematic review and meta-analysis

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British Medical Journal Open. 9:e029046. Reviewing numerous studies involving children, adults, and prenatal exposure, the authors concluded that consumption of soft drinks is associated with significantly increased odds of asthma in both adults and children, as well as marginally significant … Continue reading

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Schultz 2016: Acetaminophen use for fever in children associated with autism spectrum disorder

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Autism Open Access. April; 6(2) Because this is a study on older children, fewer of the children with autism use acetaminophen (Tylenol) as the first choice for fever reduction.  Furthermore, acetaminophen is not effective at reducing fever for significantly more … Continue reading

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Pottegard 2014: Children’s relative age in class and use of medication for ADHD: A Danish nationwide study

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Journal of Child Psychology & Psychiatry, 55(11). 1244-1250. In this study in Denmark, similar to the Zoega et al (2012) study in Iceland, the authors wanted to see if the younger children were more at risk of being prescribed ADHD … Continue reading

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Zoega 2012: Age, academic performance, and stimulant prescribing for ADHD: A nationwide cohort study

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Pediatrics, 130(6); 1012-1018 In a nationwide population-based study, the authors observed the effect of relative age on whether the child was likely to perform adequately in class and on whether the child would be prescribed medication for ADHD.  They found … Continue reading

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Zou 2011: Tourette syndrome and excitatory substances: Is there a connection?

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Child’s Nervous System, 27: 793-802. Using the same testing the International Olympic Committee uses for detecting prohibited excitatory substances, the authors attempted to find out if eating certain foods may create an excess of excitatory substances in the urine of … Continue reading

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Suglia 2013: Soft drinks consumption is associated with behavior problems in 5-year-olds

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The Journal of Pediatrics. 163(5); 1323-1328. The authors here attempted to determine the effect, if any, of soda consumption on aggressive behavior, attention problems, and withdrawn behavior among 5-year-olds.  Similar studies on older children had determined that consuming soft drinks … Continue reading

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Oplatowska-Stachowiak 2015: Food Colours: Existing and emerging food safety concerns

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Critical Reviews in Food Science and Nutrition. Feb 11;57(3):524-548. In addition to the problem of illegal and carcinogenic food dyes being added to foods — and the ongoing need to detect them — there is growing concern about the safety … Continue reading

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Rajcumar 2020: Knowledge & misconceptions of parents of children with attention-deficit hyperactivity disorder at a hospital in South Africa

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South African Family Practice,2020 Sep. 3; 62(1): e1-e8 This paper is about a survey of 79 parents of ADHD children aged 5 to 17, in South Africa.  The authors report that 92.4% of the parents believed that “reducing sugar or … Continue reading

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Howard 2010: ADHD is associated with a “Western” dietary pattern in adolescents

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Journal of Attention Disorders, 2011 Jul;15(5):403-11. Complete data, including diet and ADHD diagnoses, were obtined on 1,172 adolescents (14 year olds) from the Raine Study which had been following children from birth. The authors noted that the “Western” dietary pattern … Continue reading

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Lee 2020: Dietary patterns are associated with attention-deficit hyperactivity disorder (ADHD) symptoms among preschoolers in South Korea: A prospective cohort study

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Nutritional Neuroscience, 2020 Sep 4:1-9 In a large group of children followed from birth, data on diet and behavior were obtained on 535 children at both 4 and 6 years old. The foodsinvestigated were divided into four basic groups: Sweet:  … Continue reading

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Yan 2018: Dietary patterns are associated with attention-deficit/hyperactivity disorder (ADHD) symptoms among preschoolers in mainland China

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European Journal of Clinical Nutrition, November 2018; 72 (11):1517-1523. The authors studied several eating patterns among Chinese children.  While the “processed,” “snack,” and “beverage” dietary patterns were all positively associated with ADHD symptoms, the “vegetarian” (more natural) dietary pattern was … Continue reading

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Farsad-Naeimi 2020: Sugar consumption, sugar sweetened beverages and Attention Deficit Hyperactivity Disorder: A systematic review and meta-analysis

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Complementary Therapies in Medicine, 53 (2020) This paper is a meta-analysis of seven studies considering sugar consumption and ADHD.  The authors concluded there is a “positive relationship between overall sugar and sugar-sweetened beverages consumption and symptoms of ADHD.” The authors … Continue reading

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Bakthavachalu 2020: Food Color and Autism: A meta-analysis

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Advances in Neurobiology (2020) 24:481-504 While the research does not prove causation, there seems to clearly be a link between food dyes and symptoms of autism.  Not only are there direct neurotoxic effects, but it has been shown that at … Continue reading

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Dolp 2020: Oligoantigenic diet improved children’s ADHD rating scale scores reliably in added video-rating

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Frontiers in Psychiatry, August 2020, Volume 11, 730, pp. 1-12 An oligoantigenic diet is a few-foods diet, used sometimes to identify foods a child may be allergic to.  It excludes all the food dyes, preservatives, and other additives, as well … Continue reading

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Kirkland 2020: Artificial food coloring affects EEG power and ADHD symptoms in college students with ADHD: A pilot study.

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Kirkland AE, Langan MT, & Holton KF, Nutritional Neuroscience (2020), DOI: 10.1080/1028415X.2020.1730614 Although this is a small pilot study, and the first to consider young adults, it indicates that food dyes may affect both brainwave activity and ADHD symptoms in … Continue reading

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Fake Information Describes Feingold Diet

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Healthline Media claims to be “creating a stronger healthier world” by providing “clear, credible, evidence-based health and wellness information that’s distinguished by its compassion for the human experience.” One of its most recent articles, dated September 29, 2020, is failing … Continue reading

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Let’s get educated on vaccines

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(Updated February 14, 2023)If you have concerns about what is going on in the world of vaccines, you are not alone. I have long been collecting the research on all sides of this issue, and have begun organizing the studies … Continue reading

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How genetics and environment work together to shape our destiny: Milena Georgieva at TEDxAUBG

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Milena Georgieva is a young scientist in Bulgaria with lots of prestigious awards for best scientific excellence practices. Here, she describes the way our DNA functions. The way we live, the way we talk, the way we breathe and the … Continue reading

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Archives – FAWA 1979, July

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Dr. Feingold comments on the FDA study The Kaiser-Permanente/University of California study funded by the FDA is commonly referred to as the FDA study. The study was supportive. One child out of 22 children under controlled conditions reacted unequivocally to … Continue reading

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Archives – 1982, 01/29

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Feingold diet is worth testing, panel says American Medical News (newsletter of the American Medical Association)January 29, 1982, page 23.

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A new collection of studies on the relationship of food dyes to health

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Just finished: a compilation of all the studies I can find on the food dyes used in the US and their connection with behavior and health. Download here(190 pages) This project was created to help the California Office of Environmental … Continue reading

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Augustine 1980: Neurotransmitter Release from a Vertebrate Neuromuscular Synapse Affected by a Food Dye

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Science. 207(4438):  1489-90. Red 3 was applied to nerve synapses in the frog, producing an irreversible, dose-dependent increase in neurotransmitter release. The author suggested this may be useful for studying neurotransmitters, but that the use of Red 3 as a … Continue reading

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El-Desoky 2017: Curcumin Protects Against Tartrazine-Mediated Oxidative Stress and Hepatotoxicity in Male Rats

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European Review for Medical & Pharmacological Sciences. (21): 635-645. Curcumin (an extract of turmeric) was studied to see if it could protect against the kidney and liver damage expected from the ADI of Tartrazine (Yellow 5) given in the diet. … Continue reading

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Al-Seeni 2018: Nigella Sativa Oil Protects Against Tartrazine Toxicity in Male Rats.

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Toxicology Reports. 5: 146-155. This was not a test of tartrazine (Yellow 5) – they already knew it would be toxic.  Rats in the “positive control” group (given Yellow 5) had elevated liver enzymes, cholesterol and triglycerides, as well as … Continue reading

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Don’t miss this free seminar series

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If you, or your child, have a tic disorder or Tourette’s Syndrome, you may feel like the disorder controls your life.   But there is hope — you can manage a tic disorder, naturally, so that you feel in control. Don’t … Continue reading

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Rodrigo 2018: Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study

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Nutrients.  May 7;10(5). pii: E573. Rodrigo says that Tourette Syndrome (GTS) and gluten sensitivity may be associated.  23 children and 6 adults were put on a gluten-free diet and followed for a year.    They found a “marked reduction” in tics, … Continue reading

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Ludlow 2018: Understanding the Impact of Diet and Nutrition on Symptoms of Tourette Syndrome: A Scoping Review

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Journal of Child Healthcare. Mar;22(1):68-83 Ludlow and Rogers want to write a review of existing studies, but actually they are stuck with anecdotal reports because so little research has been done in this area.  As they say, however, “anecdotal reports … Continue reading

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Briguglio 2018: Dietary Neurotransmitters: A Narrative Review on Current Knowledge

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Nutrients. May 10;10(5). pii: E591 Some of the many substances found in foods are neurotransmitters (NT), including acetylcholine, glutamate, GABA, dopamine, serotonin and histamine.   Not only are these neurotransmitters part of the food itself, but they may be added or … Continue reading

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Dufault 2018: Food labeling requirements may explain lower autism and ADHD prevalence in the United Kingdom

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Integrative Food, Nutrition and Metabolism, 2018, 5(4): 1-2 This editorial explores possible nutritional reasons for the huge difference between the United States and the United Kingdom in numbers of children diagnosed with ADHD or autism. After two separate studies in … Continue reading

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Li 2018: Inedible Azo Dyes and Their Analytical Methods in Foodstuffs and Beverages

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Journal of AOAC International, Vol. 101.  (epublished ahead of print) This guest editorial is not about the food dyes we know and don’t love — it’s about inedible, dangerous food dyes that are used illegally in foods.  There is a … Continue reading

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Prabhakaran 2017: Benzalkonium Chloride: A Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions.

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Pharmacotherapy. 2017 May;37 (5): 607-610. Albuterol in bottles used for multiple dosing contains benzalkonium chloride (BAC) as a preservative.  The authors say that many pediatric hospitals use this kind of albuterol when preparing solutions for continuous nebulized albuterol for asthma … Continue reading

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Tseng 2018: Peripheral iron levels in children with attention-deficit hyperactivity disorder: A systematic review and meta-analysis

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Scientific Reports,  2018 Jan 15;8(1):788. 17 studies on iron and ADHD were analyzed by Tseng et al in Taiwan. Iron does more than prevent anemia; besides helping in  homeostatis of the hemoglobin (red blood cell) structure, iron is important to the … Continue reading

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Leo 2018: Occurrence of Azo Food Dyes and their Effects on Cellular Inflammatory Responses

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Nutrition. 2018 February. 46:36-40 This study found that 11.54% of the 1,681 processed items examined in a local supermarket in Singapore contained at least one of five food dyes — of which tartrazine (Yellow 5), sunset yellow (Yellow 6), and … Continue reading

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Science Library Text Collection – updated

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Today I have finally listed all the “open” research studies collected up to now.  This brings the Library Text Collection up to more than 3,000 papers listed. Now to start the next part of the project — updating the list … Continue reading

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Edelkind: Rainbow-colored cake anybody?

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In study after study, the dangers of artificial food dyes are documented.  Nevertheless, many of us would still like to provide colorful party foods for our families.  What to do?  Of course, bright fruits such as blueberries and strawberries can … Continue reading

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Feingold 1978: Address to California School Food Service Association, Sacramento, CA

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Although this speech was given in 1978, it could equally apply today.  Tragically, his warning went unheeded, and nothing has changed. Ladies and Gentlemen: I am pleased to be with you today to discuss the importance of the School Food … Continue reading

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Choudhary 2017: Neurophysiological symptoms and aspartame: What is the connection?

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Nutritional Neuroscience, 2017 Feb 15:1-11. This is a review of studies linking neuro-physiological symptoms to aspartame usage which concludes that aspartame may be responsible for adverse neurobehavioral health outcomes. QUOTE:  “Aspartame consumption needs to be approached with caution due to … Continue reading

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Soffer 2016: A case of chronic contact dermatitis resulting from the use of blue hair dye

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Contact Dermatitis. 2016 Oct;75(4): 258-9 This is a case report about a 45-year-old woman who began to dye her hair blue.  After several years of rashes and itching on her scalp, face, and neck, she sought help from an allergist.  … Continue reading

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Mawson 2017: Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children

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Journal of Translational Science, Volume 3(3): 1-12.  doi: 10.15761/JTS.1000186 This is one of the first studies done to address the questions raised by the U.S. Institute of Medicine about the long term health outcomes of the vaccination schedule as used … Continue reading

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Senate Health Committee approves Wieckowski bill to study dangers of synthetic food dyes on children

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SB 504 calls for state office to conduct independent review of evidence and options for the Legislature April 26, 2017 The Senate Health Committee today approved a bill by Senator Bob Wieckowski (D-Fremont) to direct a state agency to review … Continue reading

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Khayyat 2017: Tartrazine induces structural and functional aberrations and genotoxic effects in vivo

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PeerJ. 2017 Feb 23;5: e3041. This study was done to evaluate the possible adverse effects of the color Tartrazine (Yellow 5) on kidney and liver function and structure in rats, as well as its affect on white blood cells.  For … Continue reading

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Feitosa 2017: Estimate of the theoretical maximum daily intake of Sunset Yellow FCF by the Brazilian population

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Food Additives & Contaminants Part A. 2017 Feb 20:1-8 This study was  able to estimate daily intake of foods containing Sunset Yellow (Yellow 6) using the 2008-2009 data collections of food purchases by the Brazilian Institute of Geography and Statistics.  … Continue reading

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Bastaki 2017: Estimated Daily Intake and Safety of FD&C Food Colour Additives in the US Population

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Food Additives & Contaminants, Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 2017 March 23. Using complex statistics and a database of product  labels, rather than direct measurements, an  “estimate of daily intake” of the amounts of synthetic food … Continue reading

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Pestana 2010: Safety of ingestion of yellow tartrazine by double-blind placebo contgrolled challenge in 26 atopic adults.

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Allergologie et Immunopathologia (Madrid). 2010 May-June; 38 (3): 142-6. In this study, styling itself as a “gold standard, double-blind placebo controlled, crossed-over challenge,” 26 adults with atopy (skin or asthma allergy) were tested for tartrazine (Yellow 5) sensitivity and had … Continue reading

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