Category Archives: in vitro or lab studies

Augustine 1980: Neurotransmitter Release from a Vertebrate Neuromuscular Synapse Affected by a Food Dye

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Science. 207(4438):  1489-90. Red 3 was applied to nerve synapses in the frog, producing an irreversible, dose-dependent increase in neurotransmitter release. The author suggested this may be useful for studying neurotransmitters, but that the use of Red 3 as a … Continue reading

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El-Desoky 2017: Curcumin Protects Against Tartrazine-Mediated Oxidative Stress and Hepatotoxicity in Male Rats

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European Review for Medical & Pharmacological Sciences. (21): 635-645. Curcumin (an extract of turmeric) was studied to see if it could protect against the kidney and liver damage expected from the ADI of Tartrazine (Yellow 5) given in the diet. … Continue reading

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Al-Seeni 2018: Nigella Sativa Oil Protects Against Tartrazine Toxicity in Male Rats.

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Toxicology Reports. 5: 146-155. This was not a test of tartrazine (Yellow 5) – they already knew it would be toxic.  Rats in the “positive control” group (given Yellow 5) had elevated liver enzymes, cholesterol and triglycerides, as well as … Continue reading

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Leo 2018: Occurrence of Azo Food Dyes and their Effects on Cellular Inflammatory Responses

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Nutrition. 2018 February. 46:36-40 This study found that 11.54% of the 1,681 processed items examined in a local supermarket in Singapore contained at least one of five food dyes — of which tartrazine (Yellow 5), sunset yellow (Yellow 6), and … Continue reading

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Dixit 2013: All India survey for analyses of colors in sweets and savories: Exposure risk in Indian population

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Journal of Food Science. 2013 April; 78(4): T642-7 This is the first national study on food additive use in India, collecting data on “sweets and savories.” Their dye extraction and identification technique (using pure wool strands) is described, as is … Continue reading

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Ze 2014: Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles

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Journal of Biomedical Materials Research Part A. 2014 Feb; 102(2): 470-8. Titanium dioxide is a naturally occurring white powder approved by the FDA.  It is used as a white coloring in many products we use every day such as toothpaste, … Continue reading

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Stevens 2015: Amounts of artificial food dyes and added sugars in foods and sweets commonly consumed by children

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Clinical Pediatrics, 2015 Apr;54(4):309-21, e-published April 24, 2014 Numerous foods and candies were purchased from local stores and processed to measure the amount of food dyes actually in them. Several comprehensive tables provide the details, but below is a sample: Some … Continue reading

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Stevenson 2010: The Role of Histamine Degradation Gene Polymorphisms in Moderating the Effects of Food Additives on Children’s ADHD Symptoms

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American Journal of Psychiatry. 2010 Sep;167(9): 1108-15 Stevenson analyzed the reactions of children in the McCann (2007) study to see why not all children react to additives in the same way.  He found that variation in several genes that control … Continue reading

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Lau 2006: Synergistic Interactions Between Commonly Used Food Additives in a Developmental Neurotoxicity Test

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Toxicological Sciences. 2006 Mar; 90(1):178-87. This is one of the few studies examining and comparing the neurotoxic activity of food additives alone and in combination.   After determining how much of each additive reduces neurite development by 20%, Lau combined pairs … Continue reading

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