Category Archives: Diet Studies

Studies on the Feingold Diet, some modification of the Feingold Diet, Failsafe Diet, Oligoantigenic Diet, or simply a diet eliminating food dyes or any combination of additives. Some of these studies are double-blind with the use of a control diet, and some are not.

Jones 2023: Learning and memory deficits produced by aspartame are heritable via the paternal lineage

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Scientific Reports, Aug 31;13(1):14326. Jones, McCarthy, Stanwood, Schatschneider, Bhide Mice who drank the equivalent of only 16 oz to 32 oz of diet soda per day seemed just fine — but their babies weren’t.  Both male and female pups had … Continue reading

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Bradman 2022: Dietary Exposure to United States Food and Drug Administration-Approved Synthetic Food Colors in Children, Pregnant Women, and Women of Childbearing Age Living in the United States

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Bradman, Castorina, Thilakaratne, … Miller.  International Journal of Environmental Research and Public Health.  Aug 5;19(15):9661 The authors estimated exposure of women of child-bearing age and children to artificial food dyes.  Even though these were only one-day and two-day estimates, and … Continue reading

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Lamport 2016: Concord Grape Juice, Cognitive Function, and Driving Performance: A 12-wk, Placebo-Controlled, Randomized Crossover Trial in Mothers of Preteen Children

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Lamport, Lawton, Merat …  Dye.  American Journal of Clinical Nutrition. 103: 775-783. The intent of this study, funded by Welch Foods, was to show that grape juice improves driving ability in stressed people (moms of teens). The authors concluded that … Continue reading

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Monteiro 2023: Dietary Exposure to Food Azo-Colours in a Sample of Pre-School Children from Southern Brazil

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Food Additives & Contaminants,  Part A Chemistry, Analysis, Control, Exposure & Risk Assessment.  2023 Apr 26;1-12. doi: 10.1080/19440049.2023.2203778. Online ahead of print In Guaratuba-Parana, Brazil, the diet of 323 preschool children aged 2 to 5 years were studied for three … Continue reading

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Faraone 2014: Towards an Evidence-Based Taxonomy of Nonpharmacologic Treatments for ADHD.

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Faraone, Antshel. Child & Adolescent Psychiatric Clinics of North America. 23(4): 965-72 This paper reviews an evidence-based approach to help doctors explain to parents the relative benefits of nonpharmacologic treatments for ADHD. Food dye exclusion is given a “4” in … Continue reading

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Braganza 2006: Nutritional Interventions: Part Two. When Parents Ask About Diet Therapy for ADHD.

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Braganza, Galvez, Ozuah.  Contemporary Pediatrics. 23(5): 47-49. This paper’s stated purpose was to advise doctors on how to respond to parents asking about diet therapy for ADHD – in particular, the Feingold diet. To support their opinion, Braganza et al … Continue reading

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Kaplan 1989: Dietary replacement in preschool-aged hyperactive boys

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Pediatrics.  Jan;83(1):7-17 The authors tested a number of children using what could be called a “stage two Feingold Diet.” The diet used, in other words, eliminated food dyes and several other additives, but did not eliminate salicylate-containing foods such as … Continue reading

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Al-Shabib 2017: Unveiling the Stimulatory Effects of Tartrazine on Human and Bovine Serum Albumin Fibrillogenesis: Spectroscopic and Microscopic Study

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Spectrochimica Acta Part A:  molecular and Biomolecular Spectroscopy.  15(181(: 116-124. Tartrazine (Yellow 5) interacts with both human and bovine albumin to form amyloid fibrils such as those found in some neurodegenerative diseases such as Alzheimer’s. MedLine || Full Text

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Adams 1981: Lack of behavioral effects from Feingold Diet violations

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Perceptual and Motor Skills, 52: 307-313. (FDA study) NOTE:  The Conners’ scores for the children when they were ON the diet were not given, but it is assumed the children had actually responded to the diet before being tested on … Continue reading

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Bosch 2020: A two arm randomized controlled trial comparing the short and long term effects of an elimination diet and a healthy diet in children with ADHD (TRACE study). Rationale, study design and methods.

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Study Protocol. BioMed Central Ltd. Psychiatry. 20: 262 This study has not yet happened.  It is intended to compare two dietary treatments (an elimination diet and a “healthy” diet) and  “Care As Usual” (medication).  It is being done in the … Continue reading

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Zou 2011: Tourette syndrome and excitatory substances: Is there a connection?

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Child’s Nervous System, 27: 793-802. Using the same testing the International Olympic Committee uses for detecting prohibited excitatory substances, the authors attempted to find out if eating certain foods may create an excess of excitatory substances in the urine of … Continue reading

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Suglia 2013: Soft drinks consumption is associated with behavior problems in 5-year-olds

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The Journal of Pediatrics. 163(5); 1323-1328. The authors here attempted to determine the effect, if any, of soda consumption on aggressive behavior, attention problems, and withdrawn behavior among 5-year-olds.  Similar studies on older children had determined that consuming soft drinks … Continue reading

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Howard 2010: ADHD is associated with a “Western” dietary pattern in adolescents

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Journal of Attention Disorders, 2011 Jul;15(5):403-11. Complete data, including diet and ADHD diagnoses, were obtined on 1,172 adolescents (14 year olds) from the Raine Study which had been following children from birth. The authors noted that the “Western” dietary pattern … Continue reading

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Lee 2020: Dietary patterns are associated with attention-deficit hyperactivity disorder (ADHD) symptoms among preschoolers in South Korea: A prospective cohort study

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Nutritional Neuroscience, 2020 Sep 4:1-9 In a large group of children followed from birth, data on diet and behavior were obtained on 535 children at both 4 and 6 years old. The foodsinvestigated were divided into four basic groups: Sweet:  … Continue reading

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Yan 2018: Dietary patterns are associated with attention-deficit/hyperactivity disorder (ADHD) symptoms among preschoolers in mainland China

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European Journal of Clinical Nutrition, November 2018; 72 (11):1517-1523. The authors studied several eating patterns among Chinese children.  While the “processed,” “snack,” and “beverage” dietary patterns were all positively associated with ADHD symptoms, the “vegetarian” (more natural) dietary pattern was … Continue reading

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Dolp 2020: Oligoantigenic diet improved children’s ADHD rating scale scores reliably in added video-rating

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Frontiers in Psychiatry, August 2020, Volume 11, 730, pp. 1-12 An oligoantigenic diet is a few-foods diet, used sometimes to identify foods a child may be allergic to.  It excludes all the food dyes, preservatives, and other additives, as well … Continue reading

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Kirkland 2020: Artificial food coloring affects EEG power and ADHD symptoms in college students with ADHD: A pilot study.

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Kirkland AE, Langan MT, & Holton KF, Nutritional Neuroscience (2020), DOI: 10.1080/1028415X.2020.1730614 Although this is a small pilot study, and the first to consider young adults, it indicates that food dyes may affect both brainwave activity and ADHD symptoms in … Continue reading

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Rodrigo 2018: Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study

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Nutrients.  May 7;10(5). pii: E573. Rodrigo says that Tourette Syndrome (GTS) and gluten sensitivity may be associated.  23 children and 6 adults were put on a gluten-free diet and followed for a year.    They found a “marked reduction” in tics, … Continue reading

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Ríos-Hernández 2017: The Mediterranean Diet and ADHD in Children and Adolescents

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Pediatrics,  2017 Jan 30. pii: e20162027 This study took place in Spain, where families have a long tradition of eating the Mediterranean diet.  As diets today veer away from traditional healthful foods towards junk food, candies and convenience foods, behavior … Continue reading

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Lioutas 2015: “I saw Santa drinking soda!” Advertising and children’s food preferences

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Child Care Health & Development. 2015 May;41 (3):424-33 This study examines the “mechanisms by which food advertising prompts children’s consumer behavior.” The children respond to advertising by (1) an increase in expectations and purchase motivation, (2) happiness upon acquiring the … Continue reading

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Sommer 2015: Treatment of aspirin exacerbated respiratory disease with a low salicylate diet: a pilot crossover study.

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Otolaryngology Head & Neck Surgery. 2015 Jan; 152(1): 42-47. Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetyl-salicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis.  Treatment may include steroids, surgery, and/or aspirin desensitization. In this study of 10 patients, … Continue reading

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Sommer 2016: A novel treatment adjunct for aspirin exacerbated respiratory disease: the low-salicylate diet: a multicenter randomized control crossover trial

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International Forum of Allergy & Rhinology. 2016. April; 6(4): 385-91 30 patients diagnosed with aspirin sensitivity and aspirin-exacerbated respiratory disease (AERD) were entered into a diet trial.   They ate either a regular diet or a low-salicylate diet for 6 … Continue reading

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Zou 2011: Tourette syndrome and excitatory substances: Is there a connection?

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Childs Nervous System. 2011 May;27(5): 793-802 This is one of the first studies to investigate the relationship between dietary components and Tourette syndrome (TS). Using the laboratory that tested the Olympic Games  contestants for illegal stimulant drugs, the researchers tested … Continue reading

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Ghanizadeh 2015: The effect of dietary education on ADHD, a randomized controlled clinical trial

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Annals of General Psychiatry (2015) March 1; 14:12 This was a study on children with ADHD in Iran who were already receiving Ritalin therapy, to see if improving their diet in general might make a difference.  The children were divided … Continue reading

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Yu 2016: Sugar-Sweetened Beverage Consumption Is Adversely Associated with Childhood Attention Deficit/Hyperactivity Disorder

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International Journal of Environmental Research and Public Health, 2016 July 4;13(7). pii: E678. In this study of Taiwanese children, a strong correlation was found between amount of sugar-sweetened beverages (SSB) consumed per day and ADHD.  A dose-response effect was observed, … Continue reading

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Neuman 1978: The danger of “yellow dyes” (tartrazine) to allergic subjects

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Clinical Allergy. 1978 Jan;8(1): 65-8. In an Israeli hospital, Neuman et al tested the effect of 50 mg of tartrazine (Yellow 5) on 97 patients with a variety of allergic disorders and 25 with non-allergic rhinitis.  First, all patients were … Continue reading

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Ceserani 1978: Tartrazine and prostaglandin-system

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Prostaglandins and Medicine, 1978 Dec;1(6):499-505 The authors discuss the bronchoconstriction caused by tartrazine (Yellow 5) in people who are aspirin-sensitive, as well as its effect on the prostaglandin system of guinea pig lungs.  They found that the dye inhibits formation … Continue reading

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Stenius 1976: Hypersensitivity to acetylsalicylic acid (ASA) and tartrazine in patients with asthma

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Clinical Allergy. 1976 Mar;6(2): 119-29. In this study, Stenius and Lemola used far less of tartrazine (Yellow 5) and aspirin than what a person may normally ingest, and had to overcome chronic medication as well (see NOTES below). Nevertheless, they … Continue reading

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Settipane 1975: Aspirin intolerance. III. Subtypes, familial occurrence, and cross-reactivity with tartrazine

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Journal of Allergy and Clinical Immunology, 1975. Sep;56(3): 215-21 The authors presented their evidence that in aspirin intolerance there are two mechanisms – one causing bronchospasm (breathing difficulty such as in asthma) and the other causing urticaria (hives). They also … Continue reading

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Gesch 2002: Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners

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British Journal of Psychiatry (2002), 181,22–28 This was a double-blind, placebo-controlled, randomised study of 231 young adult prisoners.   They were given nutritional supplements used in England, and their disciplinary offenses before and after were compared. QUOTE:  “Conclusions: Antisocial behaviour … Continue reading

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Dykman 1998: Effect of nutritional supplements on attentional-deficit hyperactivity disorder

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Integrative Physiological and Behavioral Science, 1998,  Jan-Mar;33(1):49-60 This was a small study of 17 children, some on medications and some not.  During the study, some of those on medication had their meds reduced by half and some did not.  For … Continue reading

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Tomova 2015: Gastrointestinal microbiota in children with autism in Slovakia

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Physiology & Behavior 2015, Jan. 138:179-87. This is a small study showing that autism is both genetic and environmental.  The more “bad” microbes in the gut, the worse the autism, and probiotics helped. QUOTE:  “This pilot study suggests the role … Continue reading

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Bell 2013: A comparison of daily consumption of artificial dye-containing foods by American children and adults

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Eastern Michigan University Master’s Theses. 2013. Bell counted number of exposures to food dye, not the actual amounts of dye,  consumed, and she found that children are exposed to food dyes at least twice as much as adults.  She also … Continue reading

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Saab 2012: The effect of diet supplementation on children with ADHD

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Lebanese American University, Masters Thesis 2012 In a project for her Masters Degree in Education, Linda Saab performed a case study on a 9 year old boy in Beirut who was diagnosed with ADHD.   Although he was observed for 5 … Continue reading

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Pelsser 2011: Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial

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The Lancet, 2011. Feb 5;377 (9764): 494-503 This is a study of 100 children diagnosed with ADHD but not selected on any basis of expectation of a dietary effect.   The children were randomly assigned to an experimental diet group and … Continue reading

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Pelsser 2010: Effects of food on physical and sleep complaints in children with ADHD: a randomised controlled pilot study

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European Journal of Pediatrics, 2010 Sep;169(9): 1129-38. The 27 children in the Pelsser 2009 study were also evaluated for the effect of their diet condition on their sleep problems and other physical complaints.  Such complaints included headaches, bellyaches, unusual thirst, … Continue reading

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Pelsser 2009: A randomised controlled trial into the effects of food on ADHD

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European Child & Adolescent Psychiatry. 2009 Jan;18(1):12-9. In a randomized controlled trial in the Netherlands, 27 children were assigned either to an elimination diet or to a “waiting list” control group for 5 weeks, beginning after a 2-week “baseline” diet … Continue reading

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McCann 2007: Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial

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Lancet, September 6, 2007 As a followup to the earlier Bateman (2004) study, the authors retested 153  toddlers as well as 144 elementary school (8/9 years old) children from the general population.   They were briefly put on a dye-free … Continue reading

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Lien 2006: Consumption of soft drinks and hyperactivity, mental distress, and conduct problems among adolescents in Oslo, Norway

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American Journal of Public Health, 2006. Oct;96(10):1815-20 The authors surveyed almost 5,500 students in 10th grade to see how many sugar-containing soft drinks they consumed per day and to assess their mental health and conduct. AUTHORS’ CONCLUSIONS:  “High consumption levels … Continue reading

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Niederhofer 2006: A preliminary investigation of ADHD symptoms in persons with celiac disease

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Journal of Attention Disorders, 2006. Nov;10(2):200-4. Because several studies had reported a possible association of celiac disease (CD) and ADHD symptoms, the authors evaluated 132 participants diagnosed with CD – both children and adults – for ADHD symptoms before they … Continue reading

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Bateman 2004: The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children

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Archives of Disease in Childhood. 2004 Jun;89(6):506-11. The authors put 277  3-year-old children from the general population on a diet without artificial food dyes or benzoate preservatives for a week, and then challenged them at various times with a drink … Continue reading

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Pelsser 2002: Favourable effect of a standard elimination diet on the behavior of young children with attention deficit hyperactivity disorder (ADHD): a pilot study

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Nederlandsch tijdschrift voor geneeskunde 2002, Dec 28;146(52):2543-7. 36 boys and 4 girls, diagnosed with ADHD, were put on an oligoantigenic (few foods – rice, turkey, pear and lettuce) diet for two weeks.  9 children (23%) withdrew from the study because of … Continue reading

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Bennett 1998 The Shipley Project: Treating Food Allergy to Prevent Criminal Behaviour in Community Settings

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Journal of Nutritional & Environmental Medicine , Vol.8, No.1, Mar.1998, pp.77-83 All 9 children with disruptive and/or criminal behavior in this study were found to have a number of food allergies or intolerances and mineral imbalances, particularly zinc. Three also … Continue reading

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Starobrat-Hermelin 1998:   The effect of deficiency of selected bioelements on hyperactivity in children with certain specified mental disorders

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Annales Academiae Medicae Stetinensis, 1998;44:297-314 Deficiencies of magnesium, copper, zinc, calcium, and iron occur more in children with ADHD, and magnesium deficiency is the most frequent.   Starobrat-Hermelin studied a group of 110 hyperactive children who also had a variety … Continue reading

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Bennett 1997: The Health of Criminals Related to Behaviour, Food, Allergy and Nutrition: A Controlled Study of 100 Persistent Young Offenders

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Journal of Nutritional & Environmental Medicine, Vol.7, No.4 Dec 1997 pp.359-366 About 75% of persistent young offenders have behaviors linked to food sensitivity and nutrition problems; only 18% of young non-offenders have such problems. MedLine || Full Text || Get Password

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Uhlig 1997: Topographic mapping of brain electrical activity in children with food-induced attention deficit hyperkinetic disorder

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European Journal of Pediatrics, 1997. Jul;156(7):557-61. Uhlig carried out EEG brain mapping on 15 children with food-induced ADHD, both when they were on their diet and when they had been given provoking foods. Consuming the provoking foods caused a significant … Continue reading

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Boris 1994: Foods and Additives are Common Causes of the Attention Deficit Hyperactive Disorder in Children

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Annals of Allergy, May 1994, Vol. 72, pp. 462-8. 73% of 26 children with ADHD responded favorably to a diet eliminating reactive foods and artificial colors. 16 of the improved children were given a double blind challenge with 100 mg … Continue reading

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Rowe 1994: Synthetic Food Coloring and Behavior: A Dose Response Effect in a Double-Blind, Placebo-Controlled, Repeated-Measures Study

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Journal of Pediatrics, November 1994, Vol. 135, pp.691-8 150 of 200 children [75%] improved on an open trial of a diet free of synthetic food coloring, and deteriorated upon introduction of foods containing synthetic colorings. 34 other “clear” or “suspected” … Continue reading

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Carter 1993: Effects of a Few Foods Diet in Attention Deficit Disorder

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Archives of Disease in Childhood, November 1993, Vol. 69 (5), pp.564-8 59 of 78 children (75.6%) referred for “hyperactive behavior” improved on an open trial of an elimination diet.  19 of them were studied in a placebo-controlled double-blind challenge protocol. … Continue reading

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Novembre 1992: Unusual reactions to food additives

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Pediatria Medica e Chirurgica 1992 Jan-Feb;14(1):39-42 The author describes two cases of reactions to the food additives tartrazine (Yellow 5) and benzoates involving mainly the central nervous system (headache, migraine, overactivity, concentration and learning difficulties, depression) and joints (arthralgias), confirmed … Continue reading

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Pollock 1990: Effect of artificial food colours on childhood behaviour

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Pollock & Warner, Archives of Disease in Childhood, 1990.  Jan;65(1):74-7, Heart and Lung Institute, Brompton Hospital, London. Pollock did a double-blind placebo-controlled challenge study on 19 children who had improved previously on an additive-free diet.   He didn’t use any additives … Continue reading

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Sarantinos 1990: Synthetic Food Colouring and Behavioural Change in Children with Attention Deficit Disorder: A Double-Blind, Placebo Controlled, Repeated Measures Study

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Proceedings of the Nutrition Society of Australia, 1990 pg. 233. Sarantinos studied 13 children,  4-14 years old, who had been at least 6 weeks on a diet free of synthetic food dyes as part of their treatment for ADHD.  The … Continue reading

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Ward 1990: The influence of the chemical additive tartrazine on the zinc status of hyperactive children: A double-blind placebo-controlled study

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Journal of Nutritional Medicine; 1 (1). 1990. 51-58. Ward first studied the zinc status in various tissues (blood, hair, saliva, etc) in 20 hyperactive boys compared to 20 non-hyperactive boys.  Then, in a double-blind placebo-controlled study of 10 hyperactive boys … Continue reading

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Egger 1989: Oligoantigenic diet treatment of children with epilepsy and migraine

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Journal of Pediatrics, 1989. Jan;114(1):51-8. Egger put 45 children with epilepsy and recurrent headaches, abdominal symptoms, or hyperactivity on an oligoantigenic (few foods) diet.   36 of them — 80% — improved. QUOTE:  “Headaches, abdominal pains, and hyperkinetic behavior ceased … Continue reading

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Kaplan 1989: Overall Nutrient Intake of Preschool Hyperactive and Normal Boys

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Journal of Abnormal Child Psychology, April 1989, Vol. 17(2), pp.127-32. Kaplan compared food diaries of children with and without ADHD and concluded that it was idiosyncratic sensitivities to components in the diet rather than a different overall diet. MedLine || … Continue reading

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Rowe 1988: Synthetic Food Colourings and “Hyperactivity”: a Double-Blind Crossover Study

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Australian Paediatric Journal, April 1988, Vol. 24 (2), pp. 143-7 Of 220 children referred for suspected hyperactivity, 55 were put on a 6-week trial of the Feingold Diet.    40 of them — 72.7% — exhibited improved behavior, and 26 of … Continue reading

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Burlton-Bennett 1987: A Single Subject Evaluation of the K-P Diet for Hyperkinesis

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Journal of Learning Disabilities, 1987 Jun-Jul;20(6):331-5, 346. A single subject ABAB (on-off-on-off) design was used to test the effectiveness of the Feingold (K-P) diet in the treatment of a 6-year-old hyperkinetic male who seemed to  be diet-responsive.  His behavior was … Continue reading

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David 1987: Reactions to dietary tartrazine

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Archives of Disease in Childhood, 1987. Feb;62(2):119-22. In a double-blind study, David challenged 24 of his patients who had been using diet for ADHD with benzoic acid (a preservative) and a large dose of coloring — 250 mg of Yellow … Continue reading

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Gross 1987: The effect of diets rich in and free from additives on the behavior of children with hyperkinetic and learning disorders

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Journal of the American Academy of Child and Adolescent Psychiatry. 1987. Jan;26(1):53-5. Gross carried out a diet study in a summer camp which is a great way to totally control the diet and get solid results in a study. NOTE:  … Continue reading

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Schoenthaler 1986: The Impact of a Low Food Additive and Sucrose Diet on Academic Performance in 803 New York City Public Schools

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International Journal for Biosocial Research, 1986, 8(2); 185-195. Over 4 years, 803 New York City schools changed their breakfast and lunch programs.  They lowered sucrose, synthetic food color/flavors, and two preservatives (BHA and BHT). For each change, there was an … Continue reading

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